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US 12,741,997 B2Granted
Selective MCL-1 binding peptides
AssigneeMassachusetts Institute of Technology
InventorsRaheleh Rezaei-Araghi, Amy E. Keating
Life of this patent
Estimating the term…
Abstract
Provided herein are peptides that bind Mcl-1. Also provided are compositions containing these polypeptides and methods of using such peptides in the treatment of cancer that include administering to a subject one of the polypeptides.
Claims10
A compound comprising the amino acid sequence selected from the group consisting of:
- (SEQ ID NO:
- 8)
- IWBTQGChaRRLGDEINAYYARR,
- (SEQ ID NO:
- 9)
- IWBTQGH-ChaRRLGDEINAYYARR,
- (SEQ ID NO:
- 11)
- IWBAibQGChaRRLGDEINAYYARR,
- and
- (SEQ ID NO:
- 12)
- IWBAibQGH-ChaRRLGDEINAYYARR;
- wherein B is norleucine and H-Cha is homo-cyclohexylalanine.
11 more elements
A compound comprising the amino acid sequence IWBAibQGChaRRLGDEINAYYARR (SEQ ID NO:
- 11), wherein B is norleucine.
A compound comprising:
- (a) the amino acid sequence:
- IWBTQGH-ChaRRLGDEINAYYARR (SEQ ID NO:
- 9) or a variant thereof, wherein B is norleucine and H-Cha is homo-cyclohexylalanine, and wherein the variant comprises up to 3 amino acids substitutions selected from:
- B is substituted with M, L, I or V;
- T is substituted with A or V;
- and R at position 8 of SEQ ID NO:
- 9 is substituted with Q, D, Aib or Me-Leu;
- (b) the amino acid sequence:
- IWBTQGChaRRLGDEINAYYARR (SEQ ID NO:
- 8) or a variant thereof, wherein B is norleucine, and wherein the variant comprises up to 3 amino acids substitutions selected from:
- B is substituted with M, L, I or V;
- Tis substituted with A or V;
- and
- R at position 8 of SEQ ID NO:
- 8 is substituted with Q, D, Aib or Me-Leu;
- (c) the amino acid sequence:
- IWBAibQGChaRRLGDEINAYYARR (SEQ ID NO:
- 11) or variant thereof, wherein B is norleucine, and wherein the variant comprises up to 2 amino acids substitutions selected from:
- B is substituted with M, L, I or V;
- and R at position 8 of SEQ ID NO:
- 11 is substituted with Q, D, Aib or Me-Leu;
- or
- (d) the amino acid sequence:
- IWBAibQGH-ChaRRLGDEINAYYARR (SEQ ID NO:
- 12) or a variant thereof, wherein B is norleucine and H-Cha is homo-cyclohexylalanine, and wherein the variant comprises up to 2 amino acids substitutions selected from:
- B is substituted with M, L, I or V;
- and R at position 8 of SEQ ID NO:
- 12 is substituted with Q, D, Aib or Me-Leu.
25 more elements
Dependencies are inferred from the claim text.