Small molecule LIN28 inhibitors as anticancer agents
AssigneeArumugavadivel Narendran
InventorsArumugavadivel Narendran, Mohit Jain
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Abstract
LIN28 is an RNA binding protein that binds and inhibits the expression and maturation of Iet7 microRNA that carries key tumor suppressor functions. Thus, LIN28 is a feasible and effective molecular target for directed inhibition with the potential to provide therapeutic benefit to a diverse group of aggressive malignancies. The present disclosure relates generally to the Rationale, Design, Synthesis and Validation of a Novel Small Molecule Inhibitor of LIN28, coined Compound of formula (I), for the Treatment of Adult and Pediatric Malignancies. In addition, indications of this agent to block cancer metastasis, inhibit cancer stem cells to prevent relapse, and to synergize with immunotherapy, chemotherapy and radiotherapy are also been described.
Claims15
A compound of Formula (I), or a tautomer, pharmaceutically acceptable salt, or solvate thereof:
- a tautomer of Formula (P2):
- a compound of Formula (I-B), or a tautomer, pharmaceutically acceptable salt, or solvate thereof:
Dependencies are inferred from the claim text.