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US 12,741,983 B2Granted
Artificial nucleic acid, method for producing same, and use thereof
AssigneeRiken Genesis Co., Ltd.
InventorsHaruhisa Yoshikawa, Ikuya Ban, Takeshi Imanishi
Life of this patent
Estimating the term…
Abstract
Disclosed is a compound represented by formula (1) or a salt thereof wherein: “Base” represents an aromatic heterocyclic group which may have a substituent, or an aromatic hydrocarbon ring group which may have a substituent; A1 represents a single bond or an alkylene group; R1 to R5 represent an atom or a group disclosed in the specification.
Claims19
A compound represented by formula (1) or a salt thereof:
- wherein:
- “Base” represents an aromatic heterocyclic group which may have a substituent, or an aromatic hydrocarbon ring group which may have a substituent;
- A1 represents a single bond or an alkylene group;
- R1 and R2 are the same as or different from each other and independently represent a hydrogen atom, an alkyl group which may have a substituent, an alkenyl group which may have a substituent, a cycloalkyl group which may have a substituent, a cycloalkenyl group which may have a substituent, an aryl group which may have a substituent, a protecting group for a hydroxyl group, a phosphino group which has a substituent, a dihydroxyphosphinyl group which may have a substituent, or a hydroxymercaptophosphinyl group which may have a substituent, or R1, R2, two oxygen atoms respectively adjacent to R1 and R2 and carbon atoms at position-3 to position-5 in a furanose together form a ring which may have a substituent;
- R3 represents a hydrogen atom, an alkyl group which may have a substituent, an alkenyl group which may have a substituent, a cycloalkyl group which may have a substituent, an aryl group which may have a substituent, an acyl group which may have a substituent, a sulfonyl group which has a substituent, a silyl group which has a substituent, a functional molecule unit substituent, or a group represented by the formula:
- R31—X— wherein R31 represents an amino group which may have a substituent;
- and X represents an alkylene group which may have a substituent, or a group having such a structure that at least one methylene group moiety in the alkylene group is substituted by —N(R32)— wherein R32 represents a hydrogen atom or an alkyl group, —O— or —S(═O)k— wherein k represents 0, 1 or 2;
- R4 represents a hydrogen atom, an alkyl group which may have a substituent, or an aryl group which may have a substituent;
- R5 represents a hydrogen atom, an alkyl group which may have a substituent, or an aryl group which may have a substituent;
- R4 and R5 do not represent hydrogen atoms coincidentally;
- a symbol represented by the following formula:
- represents a single bond or a double bond;
- when the symbol represents a single bond, n represents 1;
- and
- when the symbol represents a double bond, n represents 0.
12 more elements
An oligonucleotide or a salt thereof, the oligonucleotide comprising a unit represented by formula (6):
- wherein:
- “Base” represents an aromatic heterocyclic group which may have a substituent, or an aromatic hydrocarbon ring group which may have a substituent;
- A1 represents a single bond or an alkylene group;
- R3 represents a hydrogen atom, an alkyl group which may have a substituent, an alkenyl group which may have a substituent, a cycloalkyl group which may have a substituent, an aryl group which may have a substituent, an acyl group which may have a substituent, a sulfonyl group which has a substituent, a silyl group which has a substituent, a functional molecule unit substituent, or a group represented by the formula:
- R31—X— wherein R31 represents an amino group which may have a substituent;
- and X represents an alkylene group which may have a substituent, or a group having such a structure that at least one methylene group moiety in the alkylene group is substituted by —N(R32)— wherein R32 represents a hydrogen atom or an alkyl group, —O— or —S(═O)k— wherein k represents 0, 1 or 2;
- R4 represents a hydrogen atom, an alkyl group which may have a substituent, or an aryl group which may have a substituent;
- R5 represents a hydrogen atom, an alkyl group which may have a substituent, or an aryl group which may have a substituent;
- R4 and R5 do not represent hydrogen atoms coincidentally;
- a symbol represented by the following formula:
- represents a single bond or a double bond;
- when the symbol represents a single bond, n represents 1;
- and
- when the symbol represents a double bond, n represents 0.
11 more elements
Dependencies are inferred from the claim text.