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US 12,741,975 B2Granted
Fused polycyclic substituted 5-carboxylic acid thienopyrimidine dione compound and use thereof
AssigneeCms Research & Development Pte. Ltd.
InventorsKevin Chen, Boyu Hu, Kai Zhou, Zhaoguo Chen, Bin Liu, Guoping Hu, Jian Li, Shuhui Chen
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Abstract
Disclosed in the present invention are a series of fused polycyclic substituted 5-carboxylic acid thienopyrimidine dione compounds and the use thereof. Specifically disclosed are a compound represented by formula (H) and a pharmaceutically acceptable salt thereof.
Claims16
A compound represented by formula (II) or a pharmaceutically acceptable salt thereof,
- wherein
- L1 and L2 are each independently selected from —(CH2)n—;
- L3 and L4 are each independently selected from —CH2—, —CH═CH—, —O— and —S—;
- R1 and R2 are each independently selected from H, OH, F, Cl, C1-3 alkyl and C1-3 alkoxy, wherein the C1-3 alkyl and C1-3 alkoxy are each independently optionally substituted with 1, 2 or 3 Ra;
- alternatively, R1 and R2 are taken together with the atom to which they are commonly attached to form a C3-6 cycloalkyl or 4- to 6-membered heterocycloalkyl, wherein the C3-6 cycloalkyl or 4- to 6-membered heterocycloalkyl is optionally substituted with 1, 2 or 3 Rb;
- R3, R4, R5, R6, R7, R8 and R9 are each independently selected from H, F, Cl, Br, I, OH, NH2, CN, C1-3 alkyl, C1-3 alkoxy and C3-6 cycloalkyl, wherein the C1-3 alkyl, C1-3 alkoxy and C3-6 cycloalkyl are each independently optionally substituted with 1, 2 or 3 Rc;
- n is selected from 0, 1 and 2;
- and
- Ra, Rb and Rc are each independently selected from H, F, Cl, Br, I, NH2 and OH.
6 more elements
A compound as shown below, or a pharmaceutically acceptable salt thereof,
Dependencies are inferred from the claim text.