Method for carrying out reaction of isatin compound and cyclopropenone compound at low catalytic amount
AssigneeSoochow University
InventorsFan Xu, Qifa Chen, Yue Teng, Zhigang Yao
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Abstract
A method for the reaction of an isatin and cyclopropenone compound at low catalytic amount. In the presence of an amine compound and phosphite, the isatin and cyclopropenone are reacted in an organic solvent using a silicon amino rare earth compound as a catalyst to synthesize pyrano[2,3-b]indol-2-one compounds. In the reaction above, the amount of catalyst is few, and noble metal is not needed for catalysis. The present method can achieve preparation of the pyrano[2,3-b]indol-2-one compound efficiently and simply.
Claims7
A method for reacting an isatin with a cyclopropenone compound at low catalytic amount, comprising the following steps:
- using a silicon amino rare earth compound as a catalyst for reacting the isatin with the cyclopropenone compound in an organic solvent in the presence of an amine compound and a phosphite ester;
- the chemical structural formula of the silicon amino rare earth compound is as follows
- wherein:
- Ln is a trivalent rare earth metal ion;
- the chemical structural formula of the amine compound is as follows:
- the general structure of the isatin is as follows:
- wherein:
- R1 is selected from the group consisting of allyl, benzyl, ethyl, methyl, and acetyl;
- R2 is selected from the group consisting of chlorine, fluorine, bromine, methyl, methoxy, nitro, trifluoromethyl, and trifluoromethoxy;
- the general structure of the cyclopropenone is as follows:
- wherein:
- Ar is selected from the group consisting of phenyl, 4-methylphenyl, 4-fluorophenyl, and 4-chlorophenyl.
Dependencies are inferred from the claim text.