Modulators of programmed death-ligand-1

A compound having a structure represented by a formula selected from:

• wherein each of n, m, and q, when present, is independently selected from 0 and 1;
• wherein X, when present, is selected from —O—, —S—, and —NR10—;
• wherein R10, when present, is selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, s-butyl, and t-butyl;
• wherein each of R1a and R1b, when present, is independently selected from hydrogen, halogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, s-butyl, and t-butyl;
• or wherein each of R1a and R1b, when present, together comprise a C3-C6 cycloalkyl;
• wherein each of R2a, R2b, and R2c, when present, is independently selected from hydrogen, halogen, and —CH2NR11aR11b, provided that at least one of R2a, R2b, and R2c is —CH2NR11aR11b;
• wherein each of R11a and R11b, when present, is independently selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, s-butyl, and t-butyl;
• wherein each of R3a and R3b is independently selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, s-butyl, and t-butyl,
• or wherein each of R3a and R3b together comprise a C3-C6 cycloalkyl;
• wherein each of R4a and R4b is independently selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, s-butyl, and t-butyl;
• and
• wherein Ar1 is selected from C6-C14 aryl and C2-C10 heteroaryl, and is substituted with 0, 1, 2, or 3 groups independently selected from halogen, —CN, —NH2, —OH, —NO2, C1-C4 alkyl, C2-C4 alkenyl, C1-C4 haloalkyl, C1-C4 cyanoalkyl, C1-C4 hydroxyalkyl, C1-C4 haloalkoxy, C1-C4 alkoxy, C1-C4 alkylamino, (C1-C4) (C1-C4) dialkylamino, and C1-C4 aminoalkyl,
• or a pharmaceutically acceptable salt thereof.