Phthalazinone compound, and preparation method therefor and medical use thereof

A compound as represented by formula (I), an optical isomer thereof, or a pharmacodynamically acceptable salt thereof,

• wherein
• R1 is selected from H, F, Cl, Br, I and C1-6 alkyl, and the C1-6 alkyl is optionally substituted with 1, 2 or 3 R;
• G is selected from H, F, Cl, Br, I and C1-6 alkyl, and the C1-6 alkyl is optionally substituted with 1, 2 or 3 R;
• ring B is selected from phenyl and 5- to 6-membered heteroaryl, and the phenyl or 5- to 6-membered heteroaryl is optionally substituted with 1, 2 or 3 R;
• ring C is C4-6 cycloalkyl;
• R2 is selected from H and C1-6 alkyl, and the C1-6 alkyl is optionally substituted with 1, 2 or 3 R;
• ring A is selected from 6- to 12-membered aryl and 5- to 12-membered heteroaryl;
• RA is selected from H, NO2, halogen, NH2, CN, C1-6 alkyl and C1-6 alkoxy, and the C1-6 alkyl or C1-6 alkoxy is optionally substituted with 1, 2 or 3 R;
• RD is selected from H, CN, halogen, C1-6 alkyl, C1-6 alkoxy, C3-6 cycloalkyl and 3- to 6-membered heterocycloalkyl, and the C1-6 alkyl, C1-6 alkoxy, C3-6 cycloalkyl or 3- to 6-membered heterocycloalkyl is optionally substituted with 1, 2 or 3 R;
• R is independently selected from H, F, Cl, Br, I, OH, NH2 and C1-6 alkyl, and the C1-6 alkyl is optionally substituted with 1, 2 or 3 R′;
• L1, L2 and L3 are independently selected from a single bond, O, S, NH, C(═O), S(═O), S(═O)2, C1-6 alkyl, —C1-6 alkyl-O—, C2-3 alkenyl, C2-3 alkynyl, C3-10 cycloalkyl, 3- to 10-membered heterocycloalkyl, phenyl and 5- to 9-membered heteroaryl, and the C1-6 alkyl, —C1-6 alkyl-O—, C2-3 alkenyl, C2-3 alkynyl, C3-10 cycloalkyl, 3- to 10-membered heterocycloalkyl, phenyl or 5- to 9-membered heteroaryl is optionally substituted with 1, 2 or 3 RL;
• RL is independently selected from H, halogen, OH, NH2, CN,
• C1-6 alkyl, C3-6 cycloalkyl, C1-6 alkyl-C(═O)—, C1-6 alkoxy, C1-6 alkylthio and C1-6 alkylamino, and the C1-6 alkyl, C3-6 cycloalkyl, C1-6 alkyl-C(—O)—, C1-6 alkoxy, C1-6 alkylthio or C1-6 alkylamino is optionally substituted with 1, 2 or 3 R′;
• R′ is independently selected from H, halogen, C1-6 alkyl, OH, NH2,
• CH3, CH2F, CHF2 and CF3;
• n is 0, 1, 2, 3 or 4;
• m is 0, 1, 2, 3 or 4;
• q is 1, 2, 3 or 4;
• and
• the 3- to 10-membered heterocycloalkyl, 3- to 6-membered heterocycloalkyl, 5- to 12-membered heteroaryl, 5- to 6-membered heteroaryl or 5- to 9-membered heteroaryl comprises 1, 2 or 3 heteroatoms or heteroatom groups independently selected from O, NH, S, C(═O), C(═O) O, S(═O), S(═O)2 and N.