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US 12,741,948 B2Granted
Benzothiazole and quinoline derivatives and their use
AssigneeShanghai Yao Yuan Biotechnology Co., Ltd.
InventorsDanyang Liu, Cong Xu, Lawrence S. Melvin, Jr., Xiong Wei, Tongruei Raymond Li, Jieqing Fan, Yanfang Pan, Huaixin Dang, Henri Lichenstein, Tian Xu
Life of this patent
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Abstract
Provided are compounds of Formula (I) or (II) and related compositions and methods for their use as inhibitors of alpha-kinase 1 (ALPK1).
Claims7
A compound having a structure of:
- wherein:
- R1 is hydrogen, halogen, —C≡CH, —C≡CH—CH3, —CX3, —CHX2, —CH2X, —OCX3, —OCH2X, —OCHX2, —OR1A, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted 2 to 6 membered heteroalkyl, or substituted or unsubstituted C3-C6 cycloalkyl;
- R2 is hydrogen or halogen;
- Each R3 and R4 is independently halogen, —OR3A, or unsubstituted C1-C6 alkyl;
- R5 is —NR5BR5C, —(CH2)n5NR5BR5C, —C(O)NR5BR5C, —O(CH2)m5OR5A, substituted or unsubstituted 5 to 6 membered heterocycloalkyl or substituted or unsubstituted C6-C12 aryl;
- R6 and R7 are hydrogen;
- or, R6 is —NR6BR6C, —(CH2)n6NR6BR6C, —C(O)NR6BR6C, —O(CH2)m6OR6A, substituted or unsubstituted 5 to 6 membered heterocycloalkyl or substituted or unsubstituted C6-C12 aryl;
- R5 and R7 are hydrogen;
- or, R7 is —NR7BR7C, —(CH2)n7NR7BR7C, —C(O)NR7BR7C, —O(CH2)m7OR7A, substituted or unsubstituted 5 to 6 membered heterocycloalkyl or substituted or unsubstituted C6-C12 aryl;
- R5 and R6 are hydrogen;
- X is independently —F, —Cl, —Br or —I;
- Each n5, n6, and n7 is independently an integer of 1 to 4;
- Each m5, m6, and m7 is independently an integer of 1 to 4;
- Each R1A, R3A, R5A, R5B, R5C, R6A, R6C, R7A, and R7C are independently hydrogen, substituted or unsubstituted C1-C4 alkyl, or substituted or unsubstituted 2 to 4 membered heteroalkyl,
- each R6B and R7B is independently substituted or unsubstituted C1-C4 alkyl, or substituted or unsubstituted 2 to 4 membered heteroalkyl, or,
- R5B and R5C together with atoms attached thereto are optionally joined to form a substituted or unsubstituted 5 to 6 membered heterocycloalkyl, or substituted or unsubstituted heteroaryl;
- R6B and R6C together with atoms attached thereto are optionally joined to form a substituted or unsubstituted 5 to 6 membered heterocycloalkyl, or substituted or unsubstituted heteroaryl;
- or R7B and R7C together with atoms attached thereto are optionally joined to form a substituted or unsubstituted 5 to 6 membered heterocycloalkyl or substituted or unsubstituted heteroaryl;
- or a salt thereof.
16 more elements
Dependencies are inferred from the claim text.