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US 12,741,933 B2Granted
Small molecule nicotinamide adenine dinucleotide modulators
AssigneeThe Cleveland Clinic Foundation
InventorsBabal Kant Jha, James G. Phillips, Jaroslaw P. Maciejewski, Frederic Joel Reu
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Abstract
Compounds that can be used to increase NAD levels are described by inhibiting NAD+ degrading enzymes such as CD38 are described. The compounds have a structure according to formula I or Formula II, as described herein, or pharmaceutically acceptable salts thereof, wherein the attached groups are as defined in the specification. Methods of increasing intracellular NAD+ levels in a subject by administering an effective amount of a compound according to formula I or formula II to the subject are also described.
Claims1
A compound having the structure
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.