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US 12,741,932 B2Granted
Isotopic thyromimetic compounds
AssigneeAutobahn Therapeutics, Inc.
InventorsBradley Backes, Thomas von Geldern
Life of this patent
Estimating the term…
Abstract
Isotopic compounds are provided that function as thyromimetics, which compounds have utility for treating diseases such as neurodegenerative disorders. Pharmaceutical compositions containing such compounds are also provided, as are methods of their use and preparation.
Claims7
A compound having the structure of Formula (VI):
- or a pharmaceutically acceptable salt or solvate thereof;
- wherein
- R is OH or OR1;
- X1 and X2 are each independently halo;
- R1 is alkyl, alkenyl, alkynyl, carbocycle, carbocyclealkyl, heterocycle or heterocyclealkyl, wherein each alkyl, carbocycle, carbocyclealkyl, heterocycle or heterocyclealkyl is optionally substituted with one or more of halo, cyano, —ORa, —NRaRb, —S(O)2Ra or —S(O)2ORa;
- each occurrence of halo is independently chloro, bromo, fluoro or iodo;
- and
- Ra and Rb is independently hydrogen or alkyl;
- and wherein at least one hydrogen atom of the compound of Formula (VI) is replaced with deuterium.
6 more elements
A compound having one of the following structures, or a pharmaceutically acceptable salt or solvate thereof:
Dependencies are inferred from the claim text.