Long-acting spleen-targeting cationic lipid compound comprising benzene ring structure, composition comprising same, and use thereof
AssigneeBeijing Youcare Kechuang Pharmaceutical Technology Co., Ltd.
InventorsGengshen Song, Honglei Zhang, Yuqing Ma, Lijie Jin, Jing Li
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Abstract
The present disclosure relates to the field of medicine, specifically to a long-acting spleen-targeting cationic lipid compound comprising a benzene ring structure, a composition comprising the same, and a use thereof. More specifically, the present disclosure provides a compound of formula (I), or an N-oxide thereof, a solvate thereof, a pharmaceutically acceptable salt thereof, or a stereoisomer thereof. The present disclosure further provides a composition comprising the aforementioned compound and a use thereof in delivering therapeutic or prophylactic agents.
Claims18
A compound of formula (I),
- or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, wherein
- G1 is C1-4 alkylene;
- G2 is C1-8 alkylene;
- G3 is C2-8 alkylene;
- R1 is C6-25 linear alkyl;
- R2 is
- R3 is C1-25 linear alkyl, C1-25 branched alkyl, or H;
- M1 is —C(O)O—, —OC(O)—, —C(O)N(R′)—, —N(R′)C(O)—, —C(O)—, or —CH(OH)—;
- M2 is —C(O)O—, —OC(O)—, —C(O)N(R′)—, —N(R′)C(O)—, —C(O)—, or —CH(OH)—;
- R′ is C1-18 alkyl or H;
- X1 is —CH— or N.
A compound, or the pharmaceutically acceptable salt thereof, or the stereoisomer thereof, wherein the compound is
A compound, or the pharmaceutically acceptable salt thereof, or the stereoisomer thereof, wherein the compound is
Dependencies are inferred from the claim text.