Microneedle particles, compositions, and methods of treatment and delivering a substance of interest
AssigneeGeorgia Tech Research Corporation
InventorsAndrew Tadros, Mark Prausnitz
Life of this patent
Estimating the term…
Abstract
Provided herein are microneedle particles, compositions that include microneedle particles, methods of treating skin, and methods of delivering a substance of interest. The microneedle particles may include one or more microneedles, and the microneedle particles may be configured to prevent the entire microneedle particle from penetrating the biological tissue. The microneedle particles may be dispersed in a liquid medium to form a composition. A biological tissue may be contacted with the microneedle particles to pre-treat the biological tissue, and a substance of interest may be applied to the pre-treated biological tissue.
Claims20
A method of treating skin of a subject, the method comprising:
- contacting a region of skin with a composition;
- wherein the contacting is effective to form a plurality of microchannels in the stratum corneum of the region of skin;
- wherein the composition comprises a plurality of microneedle particles, and a liquid medium in which the plurality of microneedle particles is dispersed;
- wherein each of the microneedle particles comprises a core structure, and one or more microneedles extending from the core structure, the one or more microneedles being structured to penetrate the stratum corneum, and wherein at least one of (i) the core structure, (ii) the one or more microneedles, and (iii) a spatial relationship between/among two or more of the microneedles is configured to prevent the entire microneedle particle from penetrating the stratum corneum.
A method of treating skin of a subject, the method comprising:
- contacting a region of skin with a composition, wherein the contacting is effective to form a plurality of microchannels in the stratum corneum of the region of skin;
- and
- contacting the region of skin with a substance of interest to produce a therapeutic effect in the subject or a cosmetic effect in the region of skin;
- wherein the composition comprises a plurality of microneedle particles, and a liquid medium in which the plurality of microneedle particles is dispersed;
- wherein each of the microneedle particles comprises a core structure, and one or more microneedles extending from the core structure, the one or more microneedles being structured to penetrate the stratum corneum, and wherein at least one of (i) the core structure, (ii) the one or more microneedles, and (iii) a spatial relationship between/among two or more of the microneedles is configured to prevent the entire microneedle particle from penetrating the stratum corneum surface;
- and
- wherein each of the one or more microneedles independently has a length of about 10 μm to about 2,000 μm.
Dependencies are inferred from the claim text.