Generating endothelial cell-seeded vascular grafts
AssigneeWisconsin Alumni Research Foundation
InventorsJames A. Thomson, Jue Zhang, John Maufort
Life of this patent
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Abstract
Provided herein are human arterial endothelial cell-seeded polymeric vascular grafts suitable for replacing or bypassing natural blood vessels and exhibiting increased long term patency rates and reduced leukocyte adhesion relative to grafts comprising venous endothelial cells. Methods for generating the human arterial endothelial cell-seeded vascular grafts and therapeutic uses of the same are also described.
Claims13
A method of treating a blood vessel defect in a subject in need thereof comprising implanting a vascular graft in the subject, wherein the vascular graft comprises (a) a polymeric substrate coated by an endothelial cell attachment agent while the polymeric substrate was in a de-gassed state and (b) human arterial endothelial cells adhered to the coated polymeric substrate.
A method of implanting a vascular graft in a subject in need thereof, wherein the vascular graft comprises (a) a polymeric substrate coated by an endothelial cell attachment agent while the polymeric substrate was in a de-gassed state and (b) human arterial endothelial cells adhered to the coated polymeric substrate.
A method of treating a blood vessel defect in a subject in need thereof comprising implanting a vascular graft in a subject, wherein the vascular graft comprises (a) a polymeric substrate coated by an endothelial cell attachment agent while the polymeric substrate was in a de-gassed state and (b) non-major histocompatibility complex matched human arterial endothelial cells adhered to the coated, polymeric substrate.
Dependencies are inferred from the claim text.