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US 12,741,059 B2Granted
Method for controlling young's modulus of three-dimensional tissue body, method for producing three-dimensional tissue body, and three-dimensional tissue body
AssigneesOsaka University, Toppan Holdings Inc.
InventorsMichiya Matsusaki, Naoko Sasaki, Shiro Kitano, Shinji Irie
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Abstract
Disclosed is a method for controlling the Young's modulus of a three-dimensional tissue containing cells and an extracellular matrix by adjusting the average diameter of an extracellular matrix in production of the three-dimensional tissue.
Claims7
A method for controlling a Young's modulus of a three-dimensional tissue containing cells and an extracellular matrix, comprising altering an average diameter of a fragmented extracellular matrix to produce the three-dimensional tissue,
- wherein the fragmented extracellular matrix consists of collagen;
- the altering an average diameter of the fragmented extracellular matrix includes altering the three-dimensional tissue to contain fragmented extracellular matrices having different average diameters while keeping a total concentration of the collagen constant,
- the fragmented extracellular matrices having different average diameters include a fragmented extracellular matrix having an average diameter in a range of 20 nm to 1000 nm and a fragmented extracellular matrix having an average diameter in a range of 1000 nm to 30 μm.
Dependencies are inferred from the claim text.