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US 12,741,053 B2Granted
Injectable and moldable tissue-mimetic elastomers and methods related thereto
AssigneeThe University of North Carolina at Chapel Hill
InventorsMohammad Vatankhan-Varnosfaderani, Sergei Sheiko, Erfan Dashtimoghadam
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Abstract
Materials and methods related to elastomers are disclosed. The disclosed elastomers are useful in implants mimicking soft tissue. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Claims19
A method comprising the steps of:
- (a) administering a first liquid polymer formulation to a subject via:
- (i) injection into a soft tissue of the subject;
- (ii) application onto a surface of a soft tissue of the subject;
- or
- (iii) injection into a pre-fabricated soft tissue implant lumen in the subject,
- wherein the first liquid polymer formulation comprises a plurality of bottlebrush polymers, wherein each bottlebrush polymer has a controlled fraction of end-functionalized side chains, and
- (b) crosslinking the plurality of bottlebrush polymers via the end-functionalized side chains, thereby forming an elastomer inside the soft tissue of the subject, onto the surface of the soft tissue of the subject, or inside the pre-fabricated soft tissue implant lumen in the subject,
- wherein the method is solvent-free or substantially solvent-free.
5 more elements
Dependencies are inferred from the claim text.