Magnetic formulations for biomarker sampling and enhanced drug delivery

A method of collecting biological material from a targeted region of a nasal cavity of a subject, the method comprising:

• inserting a device comprising a housing comprising an insertable portion for insertion into a nasal channel of the subject, configured such that upon insertion into the nasal channel of the subject, the insertable portion engages tissue within the nasal channel to open or expand an internal nasal valve of the subject;
• actuating the device;
• delivering a formulation comprising a plurality of magnetic particles to the targeted region of a subject, the plurality of magnetic particles configured to capture the biological material;
• exposing the subject to an oscillating magnetic field, the magnetic field configured to:
• (i) promote mixing of the plurality of magnetic particles within the formulation;
• and (ii) promote mixing of the formulation in the targeted region, thereby promoting capture of the biological material;
• and
• retrieving at least a portion of the plurality of magnetic particles from the targeted region,
• thereby collecting any biological material captured by the portion of the plurality of magnetic particles.