Back to results
US 12,741,031 B2Granted
Glutarimide compound and use thereof
AssigneeMedshine Discovery Inc.
InventorsMaoyi Lei, Shaohui Wang, Yu Xu, Yunfu Luo, Shuhui Chen
Life of this patent
Estimating the term…
Abstract
Disclosed in the present invention are a glutarimide compound, and the use thereof. Specifically disclosed are a compound as represented by formula (VII-0) and a pharmaceutically acceptable salt thereof.
Claims19
A compound of formula (VII-0) or a pharmaceutically acceptable salt thereof,
- wherein
- L1 is selected from
- —(CH2)3—, and —O(CH2)3—;
- L2 is selected from —CR5R6— and O;
- R1, R2, R3, R4, R5, and R6 are each independently selected from H and halogen;
- or, R1 and R2, R3 and R4, R5 and R6, optionally together with the carbon atom to which they are attached form a cyclopropyl ring;
- R7 is selected from
- R8 is selected from C1-4 alkyl, C1-4 haloalkyl, cyclopropyl, and halocyclopropyl;
- ring A is selected from
- X1 is selected from CH and N;
- X2 is selected from NH, O, S, and Se;
- ring B is selected from C5-8 cycloalkyl and 5- to 8-membered heterocycloalkyl, and the C5-8 cycloalkyl and 5- to 8-membered heterocycloalkyl are each independently and optionally substituted by 1, 2, 3, or 4 Ra;
- Ra is selected from halogen, OH, NH2, C1-3 alkyl, C1-3 alkoxy, C1-3 haloalkyl, and C1-3 haloalkoxy;
- ring C is selected from C5-8 cycloalkyl and 5- to 8-membered heterocycloalkyl, and the C5-8 cycloalkyl and 5- to 8-membered heterocycloalkyl are each independently and optionally substituted by 1, 2, 3, or 4 Rb;
- Rb is selected from halogen, OH, NH2, C1-3 alkyl, C1-3 alkoxy, C1-3 haloalkyl, and C1-3 haloalkoxy;
- the 5- to 8-membered heterocycloalkyl refers to a saturated cyclic group consisting of 5 to 8 ring atoms, wherein 1, 2, 3, or 4 ring atoms are heteroatoms independently selected from O, S, N, Si, or Se, and the rest are carbon atoms.
13 more elements
A compound of the following formulas or a pharmaceutically acceptable salt thereof,
Dependencies are inferred from the claim text.