Microparticle-assisted Treg therapy for treatment of tissue injury and fibrosis
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsHeth Turnquist, Stephen F. Badylak, George S. Hussey, Angus W. Thomson
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Abstract
Provided herein are transplantation methods and methods of treating an inflammatory condition, ischemia reperfusion injury, infection, or a wound in a patient, comprising administering isolated IL-33 matrix-bound vesicles to the patient, as well as in vitro-expanded Treg cells. Also provided is a kit comprising IL-33 matrix-bound vesicles and in vitro-expanded Treg cells.
Claims8
A method of treating a patient having an injury or inflammatory condition, comprising parenterally administering to the patient an amount of ex vivo-expanded regulatory T cells (Treg cells) effective to reduce inflammation in the patient, wherein the Treg cells are activated to produce IL-13+ by IL-33+ matrix-bound vesicles (IL-33+ MBVs), wherein the Treg cells are activated by ex vivo co-culture with the IL-33+ MBVs prior to administration to the patient.
Dependencies are inferred from the claim text.