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US 12,741,025 B2Granted
Genetically engineered phagocytes, and related compositions, vectors, methods and systems
AssigneeThe Regents of the University of California
InventorsDenise Montell, Abhinava K. Mishra, Alba Y. Torres Espinosa
Life of this patent
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Abstract
Genetically engineered activated phagocytic cells are described and related vectors, compositions, methods and systems which allow efficient cell targeting through enhanced phagocytosis of target cells and treatment of conditions in an individual.
Claims9
A genetically engineered activated phagocytic cell comprising
- an activated Rac-2 gene encoding an activated Rac-2 protein comprising an activating mutation, the activated Rac-2 gene under control of a first phagocyte promoter and a first additional phagocyte regulatory region in a configuration allowing expression of the activated Rac-2 gene in the genetically engineered activated phagocytic cell, wherein the activating mutation comprises at least one of E62K, Q61L, D63V, G12R, and G12V.
Dependencies are inferred from the claim text.