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US 12,741,010 B2Granted
Immunomodulatory and oncolytic minicells and methods of use
AssigneeVaxiion Therapeutics, Inc.
InventorMatthew J. Giacalone
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Abstract
Disclosed herein are compositions comprising immunomodulatory and oncolytic eubacterial minicells, and the use of the composition in immunomodulatory therapies for cancer. In some embodiments, the minicells are used in combination of immune checkpoint inhibitors in treating cancer.
Claims20
A method for treating cancer, comprising:
- administering a first pharmaceutical composition comprising bacterial minicells to a subject with cancer, wherein the bacterial minicells express and display invasin, wherein the bacterial minicells comprise perfringolysin O (PFO);
- and
- administering a second pharmaceutical composition comprising one or more immune checkpoint inhibitors to the subject, wherein the one or more immune checkpoint inhibitors is an antibody, wherein the first pharmaceutical composition comprises D-trehalose.
Dependencies are inferred from the claim text.