Vitamin E and cancer therapeutic compositions and methods
AssigneesUniversity of Vermont and State Agricultural College, RS Oncology, LLC, Wake Forest University Health Sciences
InventorsBrian Cunniff, Gregory Frykman, Kimberly Johnson Nelson
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Abstract
The invention relates, in part, to compounds, compositions, and methods useful to treat cancer in cells and subjects. The invention relates, in part, to compounds, compositions, and methods useful to treat cancer in cells and subjects. According to one aspect of the invention, methods for reducing cell viability in a population cells comprising cancer cells are provided, the methods including: contacting a population of cells that include cancer cells with Thiostrepton (TS) and Vitamin E-TPGS, under conditions and for a period of time sufficient for a statistically significant reduction in viability in a plurality of the cancer cells.
Claims8
A liquid pharmaceutical composition comprising Thiostrepton (TS), dimethyl sulfoxide (DMSO) and 5-10% (w/w) Vitamin E-TPGS, wherein the composition is suitable for intrapleural administration, and wherein the molar concentration of the TS in the composition is in a range from 1 mM to 5 mM.
Dependencies are inferred from the claim text.