Compositions and methods for providing hematopoietic function without HLA matching
AssigneeFred Hutchinson Cancer Center
InventorsIrwin D. Bernstein, Colleen Delaney
Life of this patent
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Abstract
The present invention relates to methods and compositions for providing hematopoietic function in immunodeficient human patients, by selecting an expanded human umbilical cord blood stem/progenitor cell sample without taking into account the HLA-type of the expanded human cord blood stem/progenitor sample or the HLA-type of the patient; and administering the selected expanded human cord blood stem/progenitor cell sample to the patient. Methods for obtaining the expanded human cord blood stem/progenitor cell samples, banks of frozen expanded human cord blood stem/progenitor cell samples, and methods for producing such banks are also provided herein.
Claims9
A method of treating acute myelogenous leukemia (AML) in a human patient, comprising:
- administering to the human patient a CD34+ enriched, T cell depleted, Notch agonist expanded human cord blood stem and progenitor (HSPC) cell product, wherein the cell product composition consists of a pool of HLA unmatched HSPC samples from at least two human donors without regard to the HLA type of the donors and without taking into account the HLA type of the human patient and a pharmaceutically acceptable carrier, excipient or buffer;
- and
- engrafting transiently cells from the HSPC cell product;
- thereby treating AML in the human patient.
Dependencies are inferred from the claim text.