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AssigneesGuangdong Ocean University, Shenzhen Institute of Guangdong Ocean University
InventorsSaiyi Zhong, Siyi Zhou, Jing Chen, Jianping Chen, Suhua Chen, Rui Li, Xuejing Jia, Xiaofei Liu
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The present disclosure provides an application of fish swim bladder-derived heparin-like mucopolysaccharide in the preparation of angiogenesis inhibitors, belonging to the technical field of medication. In the present disclosure, the structural unit of the fish swim bladder-derived heparin-like mucopolysaccharide is α-ΔGlcUA-[1→3]-GalNAc-4S. The fish swim bladder-derived heparin-like mucopolysaccharide has strong inhibition on angiogenesis. As shown from the results of examples in the present disclosure, the inhibitory rate of 400 mg/L fish swim bladder-derived heparin-like mucopolysaccharide on the growth of human umbilical vein endothelial cells can be up to 90.3%; and the inhibitory rate of 1 mg/mL fish swim bladder-derived heparin-like mucopolysaccharide on the angiogenesis of chick embryo chorioallantoic membrane is 77.15%.
A fish swim bladder-derived heparin-like mucopolysaccharide in an effective concentration for inhibiting angiogenesis, in blood vessels, wherein, the structural unit of the fish swim bladder-derived heparin-like mucopolysaccharide is α-ΔGlcUA-[1→3]-GalNAc-4S, and the fish swim bladder-derived heparin-like mucopolysaccharide comprises heparinoid accounting for 85.79±0.63% and protein accounting for 0.19±0.07%;
A composition comprising an effective concentration of a fish swim bladder-derived heparin-like mucopolysaccharide in preparation of angiogenesis inhibitors for human umbilical veins, wherein the structural unit of the fish swim bladder-derived heparin-like mucopolysaccharide is α-ΔGlcUA-[1→3]-GalNAc-4S, and the fish swim bladder-derived heparin-like mucopolysaccharide comprises heparinoid accounting for 85.79±0.63% and protein accounting for 0.19±0.07%;
A composition comprising an effective concentration of a fish swim bladder-derived heparin-like mucopolysaccharide in preparation of angiogenesis inhibitors for chick embryo chorioallantoic membrane blood vessels, wherein the structural unit of the fish swim bladder-derived heparin-like mucopolysaccharide is α-ΔGlcUA-[1→3]-GalNAc-4S, and the fish swim bladder-derived heparin-like mucopolysaccharide comprises heparinoid accounting for 85.79±0.63% and protein accounting for 0.19±0.07%;
Dependencies are inferred from the claim text.