Small molecule liver X receptor modulators and uses thereof
AssigneeUniversity of Houston System
InventorsChin-Yo Lin, Scott Gilbertson
Life of this patent
Estimating the term…
Abstract
Small molecule liver X receptor (LXR) modulators, and derivatives thereof, exhibit activity against tumor cells and less or no activity against dividing non-malignant cells, target the liver X receptor and disrupt key metabolic pathways preferred by cancer cells, and activate a newly discovered cell death mechanism which is distinct from the cell death induced by chemotherapeutic agents. These compounds can thus be a less toxic alternative to chemotherapy and can be used in combination with chemotherapy to increase efficacy and decrease the likelihood of cancer cells developing resistance. Moreover, they can be used as second-line treatments when chemotherapies are ineffective or if cancer cells develop resistance over time.
Claims4
A method for inhibiting tumor growth in a patient with advanced pancreatic cancer, triple-negative breast cancer or estrogen receptor-positive breast cancer, comprising administering a pharmaceutical formulation to the patient and modulating liver X receptor activity in the patient, wherein the pharmaceutical formulation comprises a therapeutically effective amount of a compound of formula:
- or a pharmacologically acceptable salt thereof.
A method for treating cancer in a patient with advanced pancreatic cancer, triple-negative breast cancer or estrogen receptor-positive breast cancer, comprising administering a pharmaceutical formulation to the patient and modulating liver X receptor activity in the patient, wherein the pharmaceutical formulation comprises a therapeutically effective amount of a compound of formula:
- or a pharmacologically acceptable salt thereof.
A method for inhibiting tumor growth in a patient with advanced pancreatic cancer, triple-negative breast cancer or estrogen receptor-positive breast cancer, comprising administering a pharmaceutical formulation to the patient and modulating liver X receptor activity in the patient, wherein the pharmaceutical formulation comprises a therapeutically effective amount of a compound of formula:
A method for treating cancer in a patient with advanced pancreatic cancer, triple-negative breast cancer or estrogen receptor-positive breast cancer, comprising administering a pharmaceutical formulation to the patient and modulating liver X receptor activity in the patient, wherein the pharmaceutical formulation comprises a therapeutically effective amount of a compound of formula:
Dependencies are inferred from the claim text.