Methods of treating ischemic disease by administering an ATR kinase inhibitor
AssigneeEast Tennessee State University Research Foundation
InventorsTheodoor Hagg, Yue Zou
Life of this patent
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Abstract
A method of treating a subject suffering from an ischemic disease associated with Ca2+ overload is provided, the method including administering to the subject an effective amount of an inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase. Also provided is a method of treating a subject suffering from acute ischemic stroke, the method including administering to the subject an effective amount of the ATR kinase inhibitor berzosertib.
Claims12
A method of inhibiting non-proliferating cell death associated with Ca2+ overload, the method comprising administering an effective amount of an inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase to a terminally-differentiated cell experiencing ischemic Ca2+ overload.
Dependencies are inferred from the claim text.