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US 12,740,974 B2Granted
Orally-disintegrating film comprising naratriptan
AssigneeCMG Pharmaceutical Co., Ltd.
InventorsDayeon Lee, Hyunjun Jeong, Kyoungtae Nam, Taehee Han
Life of this patent
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Abstract
An orally dissolving film formulation comprises: naratriptan, sumatriptan, eletriptan, frovatriptan, almotriptan, zolmitriptan, rizatriptan or a salt thereof as an active ingredient; and a buffer. A method for preparing an orally dissolving film formulation comprises adding a buffer to a solvent to adjust pH of the mixed solution, adding an active ingredient, a film forming agent and an additive, and applying heat, and drying to prepare a thin film.
Claims13
An orally dissolving film formulation comprising:
- a) naratriptan or a salt thereof as an active ingredient;
- and
- b) a mixture of citric acid and sodium citrate as a buffer,
- wherein the buffer comprises 0.42 to 1.05% by weight of sodium citrate and 0.015 to 0.038% by weight of citric acid based on the total weight of the film solid.
1 more element
Dependencies are inferred from the claim text.