Rapamycin-containing pharmaceutical composition
AssigneeNobelpharma AB
InventorToru Yasuzawa
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Abstract
The present invention relates to a stable rapamycin-containing composition for treating skin diseases, a method of producing the same, a method of stabilizing the same, and a method of inhibiting the degradation of rapamycin.
Claims4
A method of producing a rapamycin-containing composition for treating skin diseases, which comprises the steps of dissolving rapamycin in an ethanol-containing solvent, adding a gelling and/or thickening agent to the resulting rapamycin-containing solution, and adjusting the pH of the resulting rapamycin-containing composition to 5.5 to 6.1 with triethanolamine or tris hydroxymethyl aminomethane.
A method of inhibiting degradation of rapamycin in the rapamycin-containing composition for treating skin diseases, wherein the method comprises the step of adjusting the pH of the resulting rapamycin-containing composition to 5.5 to 6.1 with triethanolamine or tris hydroxymethyl aminomethane.
A rapamycin-containing composition for treating skin diseases comprising (i) rapamycin, (ii) carboxylic acid-containing aqueous polymer, and (iii) at least one pH adjuster selected from triethanolamine and tris-hydroxymethylaminomethane, having a pH of 5.5 to 6.1.
Dependencies are inferred from the claim text.