Methods for treating bone-related disorders
AssigneeUniversity of Maryland, Baltimore
InventorsJoseph Stains, Christopher Ward, James Lyons
Life of this patent
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Abstract
Provided herein are methods for treating a bone-related disorder in a subject. At least one of a microtubule altering drug, for example, a microtubule disrupting drug or a microtubule stabilizing drug, a TRPV4 agonist or a NOX2 activator is administered to the subject. Also provided are related methods for treating a bone-related disorder in the subject by further administering at least one of an anti-sclerostin agent, a parathyroid hormone agonist, a bisphosphonate, an estrogen mimic, or a selective estrogen receptor modulator with the at least one of a microtubule altering drug, a TRPV4 agonist or a NOX2 activator.
Claims15
A method for treating osteoporosis in a subject, comprising:
- administering to the subject an amount of a microtubule disrupting drug pharmacologically effective to treat osteoporosis,
- wherein the microtubule disrupting drug is colchicine.
A method for treating osteoporosis in a subject, comprising:
- administering to the subject one or more times an amount of a microtubule disrupting drug, or a combination of a microtubule disrupting drug and a microtubule stabilizing drug, each pharmacologically effective to treat osteoporosis,
- wherein the microtubule disrupting drug is colchicine.
A method for increasing bone mass in a subject who suffers from a bone-related disorder associated with aging, the method comprising:
- administering to the subject one or more times an amount of a microtubule disrupting drug pharmacologically effective to decrease sclerostin in the subject,
- wherein the microtubule disrupting drug is colchicine.
Dependencies are inferred from the claim text.