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US 12,740,953 B2Granted
Compositions comprising HDAC inhibitors and retinoids
AssigneeThe Regents of the University of California
InventorsYu-Jui Yvonne Wan, Kit S. Lam, Ruiwu Liu
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Abstract
The present invention provides compositions and methods comprising conjugates with a polymeric backbone, e.g., polyvinyl alcohol (PVA), covalently linked histone deacetylase (HDAC) inhibitors, such as butyrate or propionate, and covalently linked retinoids, such as all-trans retinoic acid (RA). The methods and compositions of the invention are useful for the treatment or prevention of cancer or metabolic diseases in tissues such as the colon or liver.
Claims25
A conjugate comprising:
- (a) a histone deacetylase (HDAC) inhibitor;
- (b) a retinoid;
- and (c) a polymer containing a plurality of hydroxyl groups, wherein the HDAC inhibitor and the retinoid are covalently attached to the polymer via the plurality of hydroxyl groups, and wherein the conjugate forms nanomicelles;
- wherein the HDAC inhibitor and the retinoid are covalently attached to the polymer at a molar ratio of from about 2,000:1 to about 5,000:1 HDAC inhibitor:
- retinoid.
2 more elements
Dependencies are inferred from the claim text.