Short conjugated oligoelectrolytesand antibiotics
AssigneesThe Regents of the University of California, Nanyang Technological University, National University of Singapore
InventorsGuillermo Carlos Bazan, Hengjing Yan, Jamie Hinks, Elias L. Bazan, Chenyao Nie, Jennifer Moon
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Abstract
Disclosed herein are combinations that include one or more conjugated oligoelectrolyte compounds, or pharmaceutically acceptable salts, hydrates, or solvates thereof, and one or more antibiotics. Combination of one or more conjugated oligoelectrolyte compounds and one or more antibiotics can potentiate the activity of the one or more antibiotics. Also disclosed are methods treating, reducing the severity of and/or slowing the progression of a bacterial infection, such as Gram-positive and Gram-negative bacteria, using a combination described herein.
Claims11
A method for treating, reducing the severity of and/or slowing the progression of a bacterial infection in a mammalian subject in need thereof comprising administering an effective amount of a combination of a conjugated oligoelectrolyte (COE) and an antibiotic;
- wherein the conjugated oligoelectrolyte (COE) has the structure:
- or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof,
- wherein π is any of the following:
- wherein n is 0, 1, 2 or 3;
- m is 0;
- x and u represent the numbers of substitutions on the phenyl group and are, independently, 1, 2 or 3;
- R6 and R7 are, independently, O or N;
- y and v represent the numbers of substitutions on R7 and R6, respectively, and are, independently, 1 for O, and 1 or 2 for N;
- R8 and R9 are C1-C20 alkyl;
- N⊕ each represents a quaternary ammonium or a pyridinium cationic group;
- wherein when N⊕ is a quaternary ammonium, then z and/or w are 3, and when N⊕ is a pyridinium cationic group, then z and/or w are, independently, 0, 1, 2, 3, 4 or 5;
- the counter ions comprise I−, Br−, Cl− or F−;
- and R10 and R11 are, independently, C1-C20 alkyl, optionally substituted with one or more —NH2.
Dependencies are inferred from the claim text.