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US 12,740,947 B2Granted
Method of initiating sotalol hydrochloride dosing
AssigneeAltaThera Pharmaceuticals LLC
InventorsJohn Charin Somberg, Brandon Ira Kashfian, Janos Molnar
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Abstract
This disclosure provides a method of safely and rapidly initiating or escalating oral sotalol therapy by administering an intravenous dosage of sotalol followed by oral sotalol twice daily.
Claims11
A method of administering sotalol hydrochloride therapy comprising:
- administering to a subject a single intravenous (IV) dosage of sotalol hydrochloride:
- in an amount in the range of 99 mg to 128 mg;
- over a period of 1 hour;
- and
- at a rate in the range of about 1.65 mg/min to about 2.13 mg/min;
- wherein in response to the administering of the IV dosage, the subject is capable of achieving a peak serum, plasma or blood concentration of the sotalol hydrochloride in the range of 90-110% of a Cmax at steady-state expected for that subject from oral dosing;
- and
- administering to the subject at least one 160 mg oral dose of sotalol hydrochloride and wherein the 160 mg oral dose starts at about 2-12 hours after completion of the administering of the IV dosage.
5 more elements
Dependencies are inferred from the claim text.