Headgroup lipid compounds and compositions for intracellular delivery of therapeutic agents
AssigneeModernaTX, Inc.
InventorsKerry E. Benenato, Mark Cornebise, Edward Hennessy, Andrew McKenzie
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Abstract
The invention features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
Claims14
A is a thiadiazole
- to
- A is a 1,2,5-thiadiazole.
A compound selected from Compounds 1, 2, 82, 84, 85, and 92:
- Cpd
- Structure
- 1
- 2
- 82
- 84
- 85
- 92
- and N-oxides and salts thereof.
Dependencies are inferred from the claim text.