Systems and methods for treating tissue with pulsed field ablation

A pulsed field ablation system comprising:

• a high voltage supply;
• a controller system;
• and
• a circuit communicatively connected to the controller system, the circuit electrically connected to the high voltage supply to receive input voltage therefrom, the circuit comprising:
• a first plurality of capacitors electrically connected to the high voltage supply via a plurality of switches, and
• at least a first output switch set electrically connecting the first plurality of the capacitors to a plurality of selectable pulsed field ablation electrodes,
• wherein the controller system is configured to cause:
• (i) switching of at least some of the plurality of switches to produce a first switch configuration in which the first plurality of capacitors is in a first series circuit configured to charge the first plurality of capacitors,
• (ii) switching, subsequent (i), of at least some of the plurality of switches to produce a second switch configuration in which the first plurality of capacitors is in a second series circuit configured to apply an output voltage across at least the first output switch set, the output voltage greater than the input voltage, the second series circuit different than the first series circuit, and
• (iii) switching of at least one output switch of the output switches of at least the first output switch set to generate a plurality of output pulse sets at least from energy stored at least in the first plurality of capacitors, each output pulse set in the plurality of output pulse sets configured to cause pulsed field ablation.