Conductive hydrogel paper-based device for synchronously monitoring physiological and biochemical parameters

A conductive hydrogel paper-based device for synchronously monitoring physiological and biochemical parameters, comprising a paper-based module and a flexible detection circuit module;

• wherein the paper-based module is divided into three parts, a first part of the three parts is two pieces of electrocardio electrode paper-based patches, a second part of the three parts is one piece of an electrochemical detection paper-based patch, a third part of the three parts is one piece of a paper-based microfluidic patch, and the three parts are integrated and processed on a same paper-based base layer,
• wherein each of the two pieces of the electrocardio electrode paper-based patches forms an electrocardio electrode by being added with a conductive hydrogel material through dripping on the paper-based base layer,
• wherein the electrochemical detection paper-based patch forms a working electrode by being added with the conductive hydrogel material through dripping on the paper-based base layer, and the working electrode is decorated with an electrochemically-sensitive layer,
• wherein a reference electrode and a counter electrode are both attached to the paper-based base layer to form a three-electrode system, and the conductive hydrogel material is made of a mixture of conductive polymer PEDOT:PSS and ionic liquid,
• wherein the electrocardio electrodes, the working electrode, the reference electrode, and the counter electrode are individually connected to a conductive printing port of the flexible detection circuit module through electrode connection lines,
• wherein electrical signals of the electrocardio electrodes, an electrical signal of the working electrode, an electrical signal of the reference electrode, and an electrical signal of the counter electrode are sent to the flexible detection circuit module for processing and external transmission,
• wherein a sweat collection region, a reaction region, and a sweat evaporation region are not directly connected to one another, and the sweat collection region, the reaction region, and the sweat evaporation region are arranged on a plane of the paper-based microfluidic patch,
• wherein hydrophobic treatment is performed on the rest of the plane of the paper-based microfluidic patch, and the paper-based microfluidic patch is able to make the reaction region in contact with the three-electrode system on the electrocardio electrode paper-based patches through 3D folding,
• wherein the sweat evaporation region and the sweat collection region individually contact the reaction region, and sweat collected in the sweat collection region in a folded state is able to penetrate into the reaction region through a capillary action of the paper-based base layer, contact the three-electrode system to generate an oxidation-reduction potential, and then penetrate into the sweat evaporation region to be evaporated.