Measuring neurochemical levels with multiple cyclic square wave voltammetry
AssigneesMayo Foundation for Medical Education and Research, Industry-University Cooperation Foundation Hanyang University
InventorsDong-Pyo Jang, Kendall H. Lee, Yoonbae Oh, Christopher J. Kimble
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Abstract
Systems, methods, and devices for generating multiple cyclic square-waveforms and sloped-edge square waveforms. Aspects of the techniques disclosed herein include applying the generated waveforms to an electrode used in voltammetry, e.g., to measure a level of a neurochemical in neural tissue. An electrode can be located in a solution, and an electrical stimulus applied to the solution through the electrode using a multiple cyclic square waveform. An electrical current response to the stimulus is measured, and a level of an analyte (e.g., dopamine or other neurochemical(s)) determined based on the electrical current response.
Claims8
A method for measuring a tonic level of a neurochemical in a neural tissue, comprising:
- stimulating the neural tissue with an electrical stimulus produced by a waveform generator, the electrical stimulus comprising a multiple cyclic square waveform (M-CSW);
- detecting, by an electrode in contact with the neural tissue while the neural tissue is stimulated with the electrical stimulus comprising the M-CSW, an electrical current response to the electrical stimulus, the electrical current response indicative of the tonic level of the neurochemical in the neural tissue;
- and
- adjusting, by the waveform generator, the electrical stimulus applied to the neural tissue based on the tonic level of the neurochemical indicated by the electrical current response.
Dependencies are inferred from the claim text.