Genetically modified non-human animal with human or chimeric TFR1
AssigneeBiocytogen Pharmaceuticals (Beijing) Co., Ltd.
InventorsChang Liu, Chengzhang Shang, Xiaofei Zhou
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Abstract
Provided are genetically modified non-human animals that express a human or chimeric (e.g., humanized) TFR1, and methods of use thereof.
Claims13
A genetically-modified, non-human animal whose genome comprises at least one chromosome comprising a sequence encoding a chimeric TFR1 (Transferrin Receptor Protein 1), wherein the sequence encoding the chimeric TFR1 is operably linked to an endogenous TFR1 gene's regulatory element in the at least one chromosome;
- wherein the chimeric TFR1 comprises the extracellular region of human TFR1 and the cytoplasmic region of endogenous TFR1;
- wherein the animal detectably expresses the chimeric TFR1 on the surface of one or more cells.
A genetically-modified, non-human animal whose genome comprises a replacement of a portion of an endogenous TFR1 gene encoding the extracellular region of endogenous TFR1 with the corresponding human nucleic acid sequence encoding the extracellular region of human TFR1;
- wherein the animal detectably expresses a chimeric TFR1 on the surface of one or more cells.
A method for making a genetically-modified, non-human animal, comprising:
- replacing in the genome of the animal, the portion of an endogenous TFR1 gene encoding the extracellular region of endogenous TFR1 with the corresponding human nucleic acid sequence encoding the extracellular region of human TFR1.
Dependencies are inferred from the claim text.