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US 12,736,548 B2Granted
Method for stabilizing hemoglobin
AssigneeARKRAY, Inc.
InventorYukie Kitajima
Life of this patent
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Abstract
A method that is capable of stably preserving hemoglobin in a solution. A method for stabilizing hemoglobin in a solution includes causing at least one of acetylacetone or uric acid to coexist in the solution containing hemoglobin.
Claims20
A method for stabilizing hemoglobin in a solution, including:
- preparing a hemoglobin solution by mixing hemoglobin and acetylacetone;
- and
- preserving the hemoglobin solution for a certain period of time,
- wherein
- a concentration of acetylacetone in the hemoglobin solution is 0.1 mg/mL to 2 mg/mL.
2 more elements
A method for manufacturing a calibrator for managing precision in testing hemoglobin in a biological specimen, the method comprising:
- preparing the calibrator by mixing hemoglobin and acetylacetone so that a concentration of acetylacetone is 0.1 mg/mL to 2 mg/mL.
A method for measuring hemoglobin in a biological specimen, the method comprising:
- measuring hemoglobin in a pre-prepared hemoglobin solution as a control or calibrator for measuring hemoglobin;
- and
- measuring hemoglobin in a biological specimen,
- wherein the hemoglobin solution is a hemoglobin solution that was prepared by mixing hemoglobin and acetylacetone so that a concentration of acetylacetone is 0.1 mg/mL to 2 mg/mL and has maintained a certain period of time after the preparation.
1 more element
A method for measuring hemoglobin in a biological specimen, the method comprising:
- performing stabilization treatment for stabilizing hemoglobin in a hemoglobin solution;
- performing quality control of an analysis device or a reagent by using the hemoglobin solution having been subjected to the stabilization treatment;
- and
- measuring hemoglobin in a biological specimen, using the analysis device or the reagent having been subjected to the quality control,
- wherein the stabilization treatment for stabilizing hemoglobin includes mixing hemoglobin, acetylacetone, and uric acid.
2 more elements
Dependencies are inferred from the claim text.