Conjugated composed of membrane-targeting peptides for extracellular vesicles isolation, analysis and their integration thereof

Abstract

A molecular probe comprising at least one first moiety and at least one second moiety which are each covalently bound to the molecular probe, wherein: the at least one first moiety comprises at least one binding peptide or peptidomimetic for binding the molecular probe to at least one extracellular vesicle (EV) membrane, wherein the binding is mediated by EV membrane curvature sensing; and the at least one second moiety comprises at least one support binding group for binding of the molecular probe to at least one support. The molecular probe can also comprise a spacer moiety, and/or a labeling moiety, and/or a modification moiety. The molecular probe can be bound to a solid or semi-solid support including a microarray support. The molecular probe can be used in methods in which it is contacted with sample which might include the extracellular vesicle and can involve detection and isolation steps. Kits can include the molecular probe.

Dependencies are inferred from the claim text.