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AssigneeRoche Diagnostics Operations, Inc.
InventorsFrank Bergmann, Dieter Heindl, Tobias Oelschlaegel, Johannes Stoeckel
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The present disclosure relates to a solid phase coated with (strept)avidin and having attached thereto, by way of biotin:(strept)avidin interaction, a biotinylated first member of a binding pair, wherein the attached first member is capable of binding to a second member of the binding pair, but is not capable of binding to biotin or to (strept)avidin, and wherein no member of the binding pair is capable of hybridizing with a naturally-occurring single-stranded nucleic acid. The solid phase is particularly useful in immunoassays with samples having high content in biotin or (strept)avidin-binding derivatives thereof. The present disclosure further provides uses, kits and methods, particularly for determination of an analyte in a sample.
A solid phase coated with (strept) avidin and having attached thereto, by way of <biotin:
A method of preparing a solid phase having attached thereto a member of a binding pair, the method comprising the steps of
Dependencies are inferred from the claim text.