System and method for deconvolution of real-time mass from the influence of temperature and pressure on crystal microbalance

A method of determining an incremental mass deposited on a crystal microbalance (CM) sensor comprising the steps of:

• determining (i) a first resonance frequency of a first mode frequency, and (ii) a first resonance frequency of a second mode frequency at a first time;
• determining (i) a second resonance frequency of the first mode frequency, and (ii) a second resonance frequency of the second mode frequency at a second time;
• determining (i) a first mode frequency change between the second resonance frequency of the first mode frequency and the first resonance frequency of the first mode frequency, and (ii) a second mode frequency change between the second resonance frequency of the second mode frequency and the first resonance frequency of the second mode frequency;
• determining the change in temperature of the CM sensor based on (i) the first mode frequency change, (ii) the second mode frequency change, and (iii) a plurality of coefficients based on the temperature sensitivity and mass sensitivity of the CM sensor;
• and
• determining the incremental mass deposited on the CM sensor based on (i) the change in temperature of the CM sensor, and (ii) the plurality of coefficients of the CM sensor,
• wherein the first resonance frequency and the second resonance frequency are excited alternatively.