Systems and methods for mitigating vibrations
Assignee10x Genomics, Inc.
InventorsVu Huy Nguyen, Denis Pristinski, David Morgan, Evan Dejarnette, Tyler Drake, David Hoffman
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Abstract
Various embodiments of the present disclosure disclose mitigating internal and external vibrational disturbances in opto-fluidic instrument. In various embodiments, the resonance frequency ranges and/or the vibrational frequency ranges of various modules and components of the opto-fluidic instrument may be selected to avoid resonances from occurring in the opto-fluidic instrument, thereby mitigating vibrations from internal and external sources that may distort the imaging of samples in the opto-fluidic instrument.
Claims24
A system comprising:
- a cooling system configured to vibrate at one or more frequencies within a vibrational frequency range (VFR) when the system is in operation;
- an optics module including an optical frame having a camera, an illumination module, and an X-Y stage mounted thereon, the optical frame having a first resonance frequency within a first resonance frequency range (RFR);
- and
- a chassis onto which the cooling system and the optical frame are mounted, the chassis configured to couple to a chassis vibration isolation device (a) configured to isolate the chassis from an external environment and (b) having a second resonance frequency within a second RFR, wherein:
- for a first frequency range selected from (i) the first RFR, (ii) the second RFR, and (iii) the VFR, that has higher peak frequency than a second frequency range that is different from the first frequency range and is selected from (a) the first RFR, (b) the second RFR, and (c) the VFR, a lower frequency range limit of the first frequency range is greater than a higher frequency range limit of the second frequency range by at least a factor of N>2.
A system for dampening vibrations, comprising:
- a first module configured to vibrate at one or more frequencies within a vibrational frequency range (VFR) when the system is in operation;
- a second module including a frame and a stage mounted on the frame, the frame having a first resonance frequency within a first resonance frequency range (RFR);
- and
- a vibration isolation device having a second resonance frequency within a second RFR, wherein:
- for a first frequency range selected from (i) the first RFR, (ii) the second RFR, and (iii) the VFR, that has higher peak frequency than a second frequency range that is different from the first frequency range and is selected from (a) the first RFR, (b) the second RFR, and (c) the VFR, a lower frequency range limit of the first frequency range is greater than a higher frequency range limit of the second frequency range by at least a factor of N>2;
- and
- the factor N is such that the stage experiences a vibrational displacement amplitude that is less than a threshold displacement amplitude when the system is in operation.
Dependencies are inferred from the claim text.