Back to results
US 12,735,752 B2Granted
Methods of identifying subjects having an increased risk of developing a coronavirus infection and treatment thereof
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsJack Kosmicki, Julie Horowitz, Manuel Allen Revez Ferreira, Goncalo Abecasis, Aris Baras, Amy Damask
Life of this patent
Estimating the term…
Abstract
Methods of treating subjects having a coronavirus infection, and methods of identifying subjects having an increased risk of a coronavirus infection are provided herein.
Claims17
A method of treating a subject with a therapeutic agent that treats or inhibits a coronavirus infection, wherein the subject is suffering from a coronavirus infection, the method comprising:
- determining a polygenic risk score (PRS) for the subject by:
- obtaining or having obtained a biological sample from the subject, wherein the biological sample comprises genomic nucleic acid molecule and/or mRNA;
- and
- performing or having performed a genotyping assay on the biological sample to determine if the subject has the single nucleotide polymorphism (SNP) rs2531743 or has rs2531743 and one or more of the SNPs rs73064425, rs143334143, rs9411378, rs10735079, rs2109069, rs74956615, and rs2236757,
- wherein the PRS reflects:
- i) the presence or absence of the SNPs and the homozygosity and heterozygosity of the subject for each of the SNPs;
- wherein when the subject has a PRS below a desired threshold, administering or continuing to administer to the subject the therapeutic agent that treats or inhibits the coronavirus infection in a standard dosage amount;
- and
- wherein when the subject has a PRS above a desired threshold, then administering or continuing to administer to the subject the therapeutic agent that treats or inhibits the coronavirus infection in an amount that is greater than a standard dosage amount.
6 more elements
A method of identifying a subject having an increased risk for developing a coronavirus infection or developing a severe coronavirus infection, the method comprising:
- determining a polygenic risk score (PRS) for the subject by:
- obtaining or having obtained a biological sample from the subject;
- and
- performing or having performed a genotyping assay on the biological sample to determine if the subject has the single nucleotide polymorphism (SNP) rs2531743 or has rs2531743 and one or more of the SNPs rs73064425, rs143334143, rs9411378, rs10735079, rs2109069, rs74956615, and rs2236757;
- wherein the PRS reflects:
- i) the presence or absence of the SNPs and the homozygosity and heterozygosity of the subject for each of the SNPs;
- wherein when the subject has a PRS below a desired threshold, the subject has a decreased risk for developing a coronavirus infection or developing a severe coronavirus infection;
- wherein when the subject has a PRS above a desired threshold, then the subject has an increased risk for developing a coronavirus infection or developing a severe coronavirus infection.
5 more elements
Dependencies are inferred from the claim text.