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US 12,735,745 B2Granted
FUS/TLS-based compounds and methods for diagnosis, treatment and prevention of amyotrophic lateral sclerosis and related motor neuron diseases
AssigneeThe General Hospital Corporation
InventorsThomas J. Kwiatkowski, Jr., Robert H. Brown, Jr.
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Abstract
The invention provides novel FUS/TLS nucleic acids and proteins that comprise one or more genetic markers (for example, single nucleotide polymorphisms) and methods of use thereof including methods relating to the diagnosis of ALS or other related motor neuron disease by virtue of the presence of the mutant FUS/TLS sequence(s).
Claims4
A nucleic acid probe comprising:
- (a) a nucleotide sequence consisting of 25 to 30 contiguous nucleotides of SEQ ID NO:
- 3, or a complementary sequence thereof, including position 1562, except that the nucleotide at the position corresponding to position 1562 of SEQ ID NO:
- 3 is an A;
- and
- (b) a detectable label selected from the group consisting of a fluorescent label, a radioactive label, an optical or electron density label, an energy transfer label, an epitope tag, or an enzymatic label, wherein the nucleotide sequence is coupled to the detectable label.
2 more elements
Dependencies are inferred from the claim text.