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US 12,735,737 B2Granted
Far-red dye probe formulations
AssigneeGen-Probe Incorporated
InventorsSheila Aubin Walker, Mehrdad R. Majlessi, Jimmykim Pham, Joshua Bousquet
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Abstract
Disclosed are formulations, including both liquid and lyophilized formulations, comprising a far-red dye probe and a non-linear surfactant or foamban. Also disclosed are related methods for preparing a lyophilized far-red dye probe formulation as well as related kits and diagnostic products.
Claims12
A kit comprising:
- (a) a first sealed container containing a lyophilized far-red dye probe formulation, wherein the lyophilized far-red dye probe formulation comprises
- a far-red dye probe comprising a far-red dye conjugated to a carrier molecule, wherein the far-red dye is a far-red cyanine dye and the carrier molecule is an RNA;
- a non-linear surfactant;
- and
- at least one buffering agent;
- and
- (b) a second sealed container containing a diluent, wherein the diluent comprises the non-linear surfactant at a concentration of from 1% (v/v) to about 5% (v/v);
- wherein the non-linear surfactant is present in the lyophilized far-red dye probe formulation and the diluent at concentrations configured to produce, upon reconstitution of the lyophilized formulation in the diluent, a final non-linear surfactant concentration of from about 1% (v/v) to about 10% (v/v).
5 more elements
Dependencies are inferred from the claim text.