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US 12,735,730 B2Granted
Engineered strains of Corynebacteria
OwnerShawn Manchester, Peter Enyeartinventors
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Abstract
This disclosure provides engineered strains of Corynebacteria for the cost-effective production of lysine, tools and methods used to produce the engineered strains, and methods of using the engineered strains to produce lysine.
Claims4
A Corynebacterium having a bacterial genome consisting essentially of the genome of the bacterium deposited as NRRL B-67439 but for structural alterations:
- (a) insertion of a promoter in front of the cg1383 start codon;
- (b) replacement of the native phoU promoter;
- (c) replacement of the native cg3210 promoter;
- and
- (d) replacement of the native cg0800 promoter.
2 more elements
A method of producing lysine, comprising:
- (a) culturing a Corynebacterium;
- and
- (b) recovering lysine produced by the Corynebacterium, wherein the Corynebacterium is a Corynebacterium having a bacterial genome consisting essentially of the genome of the bacterium deposited as NRRL B-67439 but for structural alterations:
- (1) insertion of a promoter in front of the cg1383 start codon;
- (2) replacement of the native phoU promoter;
- (3) replacement of the native cg3210 promoter;
- and
- (4) replacement of the native cg0800 promoter.
5 more elements
Dependencies are inferred from the claim text.