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US 12,735,721 B2Granted
Engineered adeno-associated (AAV) vectors for transgene expression
AssigneesThe General Hospital Corporation, President and Fellows of Harvard College
InventorsCasey A. Maguire, Eloise Marie Hudry, Killian S. Hanlon
Life of this patent
Estimating the term…
Abstract
Engineered AAV vectors for transgene expression, e.g., in the CNS, PNS, inner ear, heart, or retina, and methods of use thereof. Also provided are methods for discovering new engineered AAV vectors that mediate transgene expression in desired cell types.
Claims2
An adeno-associated vector (AAV) capsid protein comprising an amino acid sequence that comprises at least five contiguous amino acids from STTLYSP (SEQ ID NO:
- 1) or FVVGQSY (SEQ ID NO:2), wherein the contiguous amino acids are inserted between residues 588 and 589 of SEQ ID NO:
- 6.
Dependencies are inferred from the claim text.