Compositions and methods for inhibiting ANGPTL3 expression

An RNAi oligonucleotide for reducing angiopoietin-like protein 3 (ANGPTL3) expression, the RNAi oligonucleotide comprising a sense strand forming a duplex region with an antisense strand, wherein:

• the sense strand comprises a nucleotide sequence as set forth in sequence:
• 5′-UCAAAAUGGAAGGUUAUACAGCAGCCGAAAGGCUGC-3′ (SEQ ID NO:
• 99);
• and
• the antisense strand comprises a nucleotide sequence as set forth in sequence:
• 5′-UGUAUAACCUUCCAUUUUGAGG-3′ (SEQ ID NO:
• 100).