Filtration-based systems and methods for isolation of clustered particles

A system comprising:

• an isolation device formed by a fabricating process and comprising:
• an inlet;
• microwells, each microwell including sidewalls and a bottom surface having a meshed trapping region;
• and
• an outlet;
• wherein the device is configured to:
• receive a fluid through the inlet comprising non-clustered particles and clustered particles;
• and
• output an isolated fluid through the outlet comprising at least substantially all of the non-clustered particles and being at least substantially free of the clustered particles;
• wherein the meshed trapping region is configured to capture at least substantially all clustered particles of the fluid and pass at least substantially all non-clustered particles of the fluid;
• and
• wherein the meshed trapping region comprises at least four apertures configured to divide a flow of the fluid into at least four flow paths.