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US 12,735,507 B2Granted
Antibodies recognizing tau
AssigneeProthena Biosciences Limited
InventorsTarlochan S. Nijjar, Robin Barbour, Philip James Dolan, III, Yue Liu, Svetlana Alexander, Mark E. Renz
Life of this patent
Estimating the term…
Abstract
The invention provides antibodies that specifically bind tau. The antibodies inhibit or delay tau-associated pathologies and associated symptomatic deterioration.
Claims17
A humanized antibody or antigen-binding antibody fragment that binds specifically to human tau, comprising:
- (a) a humanized mature heavy chain variable region comprising CDRs H1, H2, and H3 comprising SEQ ID NOs:
- 8, 9, and a sequence of LDF, respectively, and a humanized mature light chain variable region comprising CDRs L1, L2, and L3 comprising SEQ ID NOs:
- 12, 13, and 14, respectively;
- (b) a humanized mature heavy chain variable region comprising CDRs H1, H2, and H3 comprising SEQ ID NOs:
- 8, 9, and a sequence of LDF, respectively, and a humanized mature light chain variable region comprising CDRs L1, L2, and L3 comprising SEQ ID NOs:
- 89, 13, and 14, respectively;
- (c) a humanized mature heavy chain variable region comprising CDRs H1, H2, and H3 comprising SEQ ID NOs:
- 8, 87, and a sequence of LDF, respectively, and a humanized mature light chain variable region comprising CDRs L1, L2, and L3 comprising SEQ ID NOs:
- 12, 13, and 14, respectively;
- (d) a humanized mature heavy chain variable region comprising CDRs H1, H2, and H3 comprising SEQ ID NOs:
- 8, 87, and a sequence of LDF, respectively, and a humanized mature light chain variable region comprising CDRs L1, L2, and L3 comprising SEQ ID NOs:
- 89, 13, and 14, respectively;
- (e) a humanized mature heavy chain variable region comprising CDRs H1, H2, and H3 comprising SEQ ID NOs:
- 86, 87, and a sequence of LDF, respectively, and a humanized mature light chain variable region comprising CDRs L1, L2, and L3 comprising SEQ ID NOs:
- 12, 13, and 14, respectively;
- (f) a humanized mature heavy chain variable region comprising CDRs H1, H2, and H3 comprising SEQ ID NOs:
- 86, 87, and a sequence of LDF, respectively, and a humanized mature light chain variable region comprising CDRs L1, L2, and L3 comprising SEQ ID NOs:
- 89, 13, and 14, respectively;
- (g) a humanized mature heavy chain variable region comprising CDRs H1, H2, and H3 comprising SEQ ID NOs:
- 86, 88, and a sequence of LDF, respectively, and a humanized mature light chain variable region comprising CDRs L1, L2, and L3 comprising SEQ ID NOs:
- 12, 13, and 14, respectively;
- (h) a humanized mature heavy chain variable region comprising CDRs H1, H2, and H3 comprising SEQ ID NOs:
- 86, 88, and a sequence of LDF, respectively, and a humanized mature light chain variable region comprising CDRs L1, L2, and L3 comprising SEQ ID NOs:
- 89, 13, and 14, respectively;
- (i) a humanized mature heavy chain variable region comprising CDRs H1, H2, and H3 comprising SEQ ID NOs:
- 86, 92, and a sequence of LDF, respectively, and a humanized mature light chain variable region comprising CDRs L1, L2, and L3 comprising SEQ ID NOs:
- 12, 13, and 14, respectively;
- or
- (j) a humanized mature heavy chain variable region comprising CDRs H1, H2, and H3 comprising SEQ ID NOs:
- 86, 92, and a sequence of LDF, respectively, and a humanized mature light chain variable region comprising CDRs L1, L2, and L3 comprising SEQ ID NOs:
- 89, 13, and 14, respectively;
- wherein Kabat positions L7, L10, L15, L17, L37, L45, L83, L86, L100, and L106 are occupied by S, S, L, E, Q, R, V, Y, Q, and I, respectively.
29 more elements
Dependencies are inferred from the claim text.