Anti D-Dimer recombinant antibodies, methods and uses thereof
AssigneeF. Hoffmann-La Roche AG
InventorsElizabeth A. Booth, Charles Holz, Tristan Wasley, Virginia Montanini, Jody Berry
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Abstract
This application relates to anti-D-Dimer recombinant antibodies that specifically bind to fibrin and fibrinogen degradation products (FDP) such as D-Dimer, fragment DD and fragment D with high binding affinity and do not bind to fragment E and fibrinogen. The present invention also refers to methods and assays for detection of D-Dimer and FDP fragments in samples using said recombinant antibodies.
Claims12
An anti-D-dimer recombinant antibody that specifically binds to fibrin degradation products and fibrinogen degradation products, wherein the fibrin degradation products and the fibrinogen degradation products include D-Dimer, fragment DD and fragment D, but the recombinant antibody does not bind to either fragment E and fibrinogen, wherein fragment E is a fibrin degradation product or a fibrinogen degradation product, and wherein the anti-D-dimer recombinant antibody comprises:
- a light chain variable region comprising the amino acid sequence of SEQ ID NO:
- 31 (L-CDR1);
- the amino acid sequence of SEQ ID NO:
- 32 (L-CDR2);
- and the amino acid sequence of SEQ ID NO:
- 33 (L-CDR3);
- and
- a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 34 (H-CDR1);
- an amino acid sequence selected from the group consisting of SEQ ID NO:
- 35, SEQ ID NO:
- 37, and SEQ ID NO:
- 38 (H-CDR2);
- and the amino acid sequence of SEQ ID NO:
- 36 (H-CDR3).
Dependencies are inferred from the claim text.